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They also have an increased risk of developing cancer particularly cancer of blood-forming cells and cancer of immune system cells. Orthologs are common in other vertebrate species whereas invertebrate genomes may encode a more distantly related gene.

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Affected individuals are very sensitive to the effects of radiation exposure including medical x-rays.

. The life expectancy of people with ataxia-telangiectasia varies greatly but affected individuals typically live into early adulthood. BRCA1 is a human tumor suppressor gene also known as a caretaker gene and is responsible for repairing DNA. Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the BRCA1 ˌ b r æ k ə ˈ w ʌ n gene.

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